Antidiabetic Activity from Gallic Acid Encapsulated Nanochitosan

11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

材料科学;化学;生物科学

Purbowatiningrum^1 ; Ngadiwiyana^1 ; Ismiyarto^1 ; Fachriyah, E.^1 ; Eviana, I.^1 ; Eldiana, O.^1 ; Amaliyah, N.^1 ; Sektianingrum, A.N.^1

Chemistry Department, Science and Mathematics Faculty, Diponegoro University, Jl. Prof. H. Soedarto, SH, Tembalang, Semarang

50275, Indonesia^1

关键词: Absorption process;    Alpha glucosidase;    Antidiabetic activity;    Bioactive compounds;    Chitosan nanoparticles;    Diabetes mellitus;    Encapsulation efficiency;    Phenolic compounds;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/172/1/012042/pdf
DOI  :  10.1088/1757-899X/172/1/012042

来源: IOP

【 摘 要 】

Diabetes mellitus (DM) has become a health problem in the world because it causes death. One of the phenolic compounds that have antidiabetic activity is gallic acid. However, the use of this compound still provides unsatisfactory results due to its degradation during the absorption process. The solution offered to solve the problem is by encapsulated it within chitosan nanoparticles that serve to protect the bioactive compound from degradation, increases of solubility and delivery of a bioactive compound to the target site by using freeze-drying technique. The result of chitosan nanoparticle's Scanning Electron Microscopy (SEM) showed that chitosan nanoparticle's size is uniform and it is smaller than chitosan. The value of encapsulation efficiency (EE) of gallic acid which encapsulated within chitosan nanoparticles is about 50.76%. Inhibition test result showed that gallic acid-chitosan nanoparticles at 50 ppm could inhibite α-glucosidase activity in 28.87% with 54.94 in IC50.So it can be concluded that gallic acid can be encapsulated in nanoparticles of chitosan and proved that it could inhibit (α-glucosidase.