Inhibition of α-Glucosidase, Total Phenolic Content and Flavonoid Content on Skin Fruit and Flesh Extracts of Some Varieties of Snake Fruits

3rd International Seminar On Sciences "Sciences On Precision And Sustainable Agriculture"

Rohaeti, E.^1 ; Fauzi, M.R.^1 ; Batubara, I.^1,2

Department of Chemistry, Bogor Agriculture University, Indonesia^1

Tropical Biopharmaca Research Center, Bogor Agricultural University, Indonesia^2

关键词: Alpha glucosidase;    Antidiabetic activity;    Flavonoid content;    Fruit extracts;    Gallic acids;    Phenolic content;    Total flavonoid contents;    Total phenolic content;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/58/1/012066/pdf
DOI  :  10.1088/1755-1315/58/1/012066

来源: IOP

【 摘 要 】

This study aimed to determine the antidiabetic activity of the skin fruit and flesh of snack fruit through α-glucosidase inhibition and correlated with total phenolic and flavonoid content as well as thin layer chromatography bio-autography. Seven varieties of varieties of skin and flesh of the fruits each extracted by maceration using ethanol 70%. The results show the highest power of the α-glucosidase inhibition obtained at Manonjaya skin extract with IC50value of 17.9 μg/mL. The TLC pattern indicates the presence of four active spot on skin extract and two spots on flesh extracts on the use of solvent BuOH:HAc:water (6:2:2). The highest phenolic content obtained at skin fruit extract of Salak Mawar 186.15 ± 1.66 mg of gallic acid equivalents per gram extract. The highest total flavonoid content obtained in Salak Malaka skin fruit extract that is 7:43 ± 0:04 milli gram of quercetin equivalents.