Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits

Arabian Journal of Chemistry

卷:14

P. Arumugam¹  R. Bharkavi¹  K. Saraswathi²  Ameer Khusro³  Muhammad Umar Khayam Sahibzada⁴  Azzah M. Bannunah⁵  Anas S. Dablool⁶  Mazen Almehmadi⁷  Saad Alghamdi⁸  C. Sivaraj⁹ 

[1] Corresponding authors.;

[2] Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Madhuranthagam, Kancheepuram 603308, Tamil Nadu, India;

[3] Department of Biotechnology, Pavendar Bharathidasan College of Engineering and Technology, Thanjai Natarajan Nagar, Mathur, Pudukottai Road, Tiruchirappalli 620024, Tamil Nadu, India;

[4] Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia;

[5] Department of Public Health, Health Sciences College at Al-Leith, Umm Al-Qura University, Makkah, Saudi Arabia;

[6] Industrial Fermentation Technology, ARMATS Biotek Training and Research Institute, Guindy, Chennai 600032, Tamil Nadu, India;

[7] Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O.Box.715, Makkah 21955, Saudi Arabia;

[8] Phytochemistry and Natural products Laboratory, ARMATS Biotek Training and Research Institute, Guindy, Chennai 600032, Tamil Nadu, India;

[9] Research Department of Plant Biology and Biotechnology, Loyola College, Chennai 600034, Tamil Nadu, India;

关键词: Fruit extracts;    GC–MS;    Medicinal properties;    Solanum virginianum;   

DOI  :  

来源: DOAJ

【 摘 要 】

The study was aimed to screen the presence of phytoconstituents and determine distinct in vitro medicinal traits of aqueous and ethanolic extracts of Solanum virginianum dried fruits. Aqueous and ethanolic extract showed total phenolic content of 207.5 ± 0.16 and 268.4 ± 0.42 GAE/mg, respectively. Likewise, total flavonoid content of 50.12 ± 0.39 and 192.88 ± 0.27 QE/mg was estimated for the aqueous and ethanolic extract, respectively. In vitro antibacterial, antioxidant, α-amylase inhibition, anti-inflammatory, and anticancer attributes of extracts were assessed using standard protocols. The antibacterial traits of both the extracts were assessed against certain pathogenic bacteria which exhibited maximum zone of inhibition of 22.3 ± 0.6 mm against Staphylococcus aureus. Antioxidant tests showed not only significant scavenging of DPPH, superoxide, hydroxyl, and ABTS●+ radicals but also estimated ferric reducing power and phosphomolybdenum reduction activities of extracts in a concentration dependent manner. The aqueous extract (54.12 ± 0.44–86.80 ± 0.27%) depicted higher rate of α-amylase inhibition than ethanolic extract (23.07 ± 0.47–81.61 ± 0.43%) at distinct concentrations. Similarly, the aqueous extract protected the haemolysis (46.19 ± 0.14–66.21 ± 0.17%) effectively as compared to the ethanolic extract (12.67 ± 0.19–38.03 ± 0.41%). The aqueous and ethanolic extract showed cytotoxicity against HepG2 cell lines in the range of 32.23 ± 0.34–54.82 ± 0.26% and 49.25 ± 0.38–73.2 ± 0.3%, respectively. Additionally, the GC–MS analysis confirmed the availability of total 15 predominant bioactive constituents in both extracts. Findings of this context indicated pronounced applications of S. virginianum fruits as future therapeutic.

【 授权许可】

Unknown