Effect of superfine pulverization on physicochemical and medicinal properties of Qili Powder

Revista Brasileira de Farmacognosia

Shaanxi Normal University,, Xi’an, China¹  JiangXi University of Traditional Chinese Medicine, Nanchang, China¹  Li, Zhe¹  Xiong, Zhiwei¹  Liao, Zhenggen¹  Shannxi Academy of Traditional Chinese Medicine, Xi'an, China¹  Liang, Xinli¹  Wang, Chunliu¹  Zhao, Guowei¹ 

关键词: Medicinal properties;    Physicochemical properties;    Qili Powder;    Superfine pulverization;   

DOI  :  10.1016/j.bjp.2014.09.006

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Qili Powder, a preparation from Traditional Chinese Medicine, commonly used to treat injuries from falling or stumbling, pain caused by bruising, and traumatic hemorrhage. The aim of the present work was to investigate the application of the superfine pulverization on Qili Powder properties. The physicochemical and medicinal properties of fine Qili Powder with D90 particle size of 164.5 μm, and superfine Qili Powder with D90 particle size of 32.2 μm were investigated. The results showed that with decreasing particle size, the specific surface area and pore volume increased, the fluidity decreased, and the percentage of moisture absorption and the balanced moisture content decreased. Analysis HPLC, XRD and FTIR results indicated that superfine pulverization didn’t influence dracorhodin content, nor the molecular structure and crystal form of Qili Powder. The percentage of dissolution of dracorhodin was significantly improved after superfine pulverization. Pharmacokinetics results confirmed that superfine pulverization increases the absorption rate in rats and dracorhodin content of Qili Powder.

【 授权许可】

Unknown