Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus

BMC Complementary and Alternative Medicine

Research Article

Shakeel Ahmad¹  Atif Nisar Ahmad²  Luigi Aliberti³  Vincenzo De Feo³  Shahzad Zafar Iqbal⁴  Roselina Karim⁴  Muhammad Tauseef Sultan⁵  Masood Sadiq Butt⁶  Muhammad Zia-Ul-Haq⁷ 

[1] Department of Agronomy, Bahauddin Zakariya University Multan, Multan, Pakistan;Department of Pathobiology, Bahauddin Zakariya University Multan, Multan, Pakistan;Department of Pharmacy, University of Salerno, Salerno, Italy;Faculty of Food Science and Technology, University of Putra Malaysia, Putra, Malaysia;Faculty of Food Science and Technology, University of Putra Malaysia, Putra, Malaysia;Department of Food Sciences, Bahauddin Zakariya University Multan, Multan, Malaysia;National Institute of Food Science & Technology, University of Agriculture, Faisalabad, Pakistan;The Patent Office, Karachi, Pakistan;

关键词: Nigella sativa;    Traditional uses;    Diabetes mellitus;    Hyperglycemia;    Oxidative stress;   

DOI  :  10.1186/1472-6882-14-193

 received in 2013-12-02, accepted in 2014-05-21,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundNigella sativa fixed (NSFO) and essential (NSEO) oils have been used to treat diabetes mellitus and its complications. Present study was undertaken to explore and validate these folkloric uses.MethodsSprague dawley rats having streptozotocin (STZ) induced diabetes mellitus were used to assess the role of NSFO and NSEO in the management of diabetes complications. Parameters investigated were antioxidant potential, oxidative stress, and the immunity by in vivo experiments.ResultsThe results indicated that STZ decreased the glutathione contents (25.72%), while NSFO and NSEO increased the trait significantly (P < 0.05). Experimental diets increased the tocopherol contents (P < 0.01) and enhanced the expression of hepatic enzymes (P < 0.01). Correlation matrix further indicated that antioxidant potential is positively associated (P < 0.05) responsible for the modulation of hepatic enzymes and the decrease of the nitric oxide production thus controlling the diabetes complications.ConclusionsOverall, results of present study supported the traditional use of N. sativa and its derived products as a treatment for hyperglycemia and allied abnormalities. Moreover, N. sativa fixed and essential oils significantly ameliorate free radicals and improve antioxidant capacity thus reducing the risk of diabetic complications.

【 授权许可】

Unknown   
© Sultan et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.