Thresholds of Oxidative Stress in Newly Diagnosed Diabetic Patients on Intensive Glucose-Control Therapy

PLoS One

Rashmi Kulkarni¹  Jhankar Acharya²  Saroj Ghaskadbi²  Pranay Goel³ 

[1] Department of Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, India;Department of Zoology, University of Pune, Pune, Maharashtra, India;Mathematics and Biology, Indian Institute of Science Education and Research, Pune, Maharashtra, India

关键词: Diabetes mellitus;    Glucose;    Glutathione;    HbA1c;    Antioxidants;    Oxidative stress;    Insulin;    Hyperglycemia;   

DOI  :  10.1371/journal.pone.0100897

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Cellular and animal studies suggest that oxidative stress could be the central defect underlying both beta-cell dysfunction and insulin resistance in type 2 diabetes mellitus. A reduction of glycemic stress in diabetic patients on therapy alleviates systemic oxidative stress and improves insulin resistance and beta-cell secretion. Monitoring oxidative stress systematically with glucose can potentially identify an individual's recovery trajectory. To determine a quantitative model of serial changes in oxidative stress, as measured via the antioxidant glutathione, we followed patients newly diagnosed with diabetes over 8 weeks of starting anti-diabetic treatment. We developed a mathematical model which shows recovery is marked with a quantal response. For each individual the model predicts three theoretical quantities: an estimate of maximal glutathione at low stress, a glucose threshold for half-maximal glutathione, and a rate at which recovery progresses. Individual patients are seen to vary considerably in their response to glucose control. Thus, model estimates can potentially be used to determine whether an individual patient's response is better or worse than average in terms of each of these indices; they can therefore be useful in reassessing treatment strategy. We hypothesize that this method can aid the personalization of effective targets of glucose control in anti-diabetic therapy.

【 授权许可】

CC BY