Natural products improve healthspan in aged mice and rats: A systematic review and meta-analysis

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:121

Review

Musillo, Chiara^1,2  Borgi, Marta¹  Saul, Nadine³  Moeller, Steffen⁴  Luyten, Walter⁵  Berry, Alessandra¹  Cirulli, Francesca¹ 

[1] Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Viale Regina Elena 299, I-00161 Rome, Italy

[2] Sapienza Univ Rome, Dept Psychol, PhD Program Behav Neurosci, Rome, Italy

[3] Humboldt Univ, Inst Biol, Fac Life Sci, Mol Genet Grp, Philippstr 13, D-10115 Berlin, Germany

[4] Rostock Univ, Med Ctr, Inst Biostat & Informat Med & Ageing Res, D-18057 Rostock, Germany

[5] Katholieke Univ Leuven, Biol Dept, Leuven, Belgium

关键词: Mice;    Rats;    Animal model;    Ageing;    Memory;    Dietary supplements;    Metabolism;    Physiological stress;    Locomotion;    Healthy ageing;   

DOI  :  10.1016/j.neubiorev.2020.12.001

来源: Elsevier

【 摘 要 】

Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; healthspan is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth.

【 授权许可】

Free