Effect of statin on vascular wall thickness in kidney disease model

3rd Annual Applied Science and Engineering Conference

工业技术;自然科学

Cahyawati, P.N.^1 ; Arfian, N.^2 ; Ngatidjan, N.^3

Department of Pharmacology and Pharmacy, Faculty of Medicine and Health Sciences, Warmadewa University, Bali, Indonesia^1

Department of Anatomy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia^2

Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia^3

关键词: Animal model;    Chronic renal failure;    Interstitial tissues;    Kidney disease;    Muscular arteries;    Simvastatin;    Vascular wall;    Wall thickness;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/434/1/012324/pdf
DOI  :  10.1088/1757-899X/434/1/012324

来源: IOP

【 摘 要 】

Fibrosis is a major histopathologic feature of kidney disease especially chronic renal failure. Fibrosis can occur in the glomerulus, tubules, interstitial tissue and blood vessels. Fibrosis in blood vessels is usually characterized by thickening and loss of elasticity of muscular arteries walls. This study focus to assess the effect of statin on the wall thickness of blood vessels in kidneys tissue with the animal model of kidney disease. A total of 18 male swiss was used in these study. All the animal divided into 4 groups: sham group (S, n = 4), subtotal nephrectomy (SN, n = 4), simvastatin group 10 mg/kgBB (SIM10, n = 5), and simvastatin group 20 mg/kgBB (SIM20, n = 5). The kidneys tissue is stained with picrosirius red staining. Wall thickness on vascular kidneys is measured at the end of the study by Image J software. After 2 weeks of study, we found that the fraction area of wall thickness in SO group is significantly lower compared with the SN group (8.35?1.47 vs 26.86?6.39, p