Revolution in mitochondrial medicine

FEBS Letters

Larsson, Nils-Göran¹  Luft, Rolf² 

[1] Department of Molecular Medicine, CMM L8:02, Karolinska Hospital, S-171 76 Stockholm, Sweden;Rolf Luft Research Center, Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden

关键词: Mitochondrial dysfunction;    Nuclear gene mutation;    Ageing;    Animal model;    ANT;    adenine nucleotide translocator;    CoQ;    coenzyme Q;    COX;    cytochrome c oxidase;    mtDNA;    mitochondrial DNA;    ROS;    reactive oxygen species;    SDH;    succinate dehydrogenase;    SOD;    superoxide dismutase;    Tfam;    mitochondrial transcription factor A;   

DOI  :  10.1016/S0014-5793(99)00854-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A revolution in chemical pathology occurred about 40 years ago with the discovery of a patient with mitochondrial dysfunction. The field of mitochondrial medicine has experienced explosive growth during the last decade. More than 50 mtDNA mutations and several nuclear gene mutations have been identified in affected patients. The recent development of animal models will continue the revolution in mitochondrial medicine by facilitating in depth studies of the molecular pathogenesis and development of novel drug and gene therapy strategies for mitochondrial dysfunction. As we enter the next millennium, we can expect mitochondrial medicine to remain a dynamic and rapidly developing field.

【 授权许可】

Unknown