Obesity and sex interact in the regulation of Alzheimer's disease

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:67

Article; Proceedings Paper

Moser, V. Alexandra¹  Pike, Christian J.^1,2 

[1] Univ Southern Calif, Neurosci Grad Program, Los Angeles, CA 90089 USA

[2] Univ Southern Calif, Davis Sch Gerontol, 3715 McClintock Avenue, Los Angeles, CA 90089 USA

关键词: Alzheimer's disease;    beta-amyloid;    Apolipoprotein E;    Estrogen;    Inflammation;    Obesity;    Sex differences;    Testosterone;   

DOI  :  10.1016/j.neubiorev.2015.08.021

来源: Elsevier

【 摘 要 】

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, for which a number of genetic, environmental, and lifestyle risk factors have been identified. A significant modifiable risk factor is obesity in mid-life. Interestingly, both obesity and AD exhibit sex differences and are regulated by sex steroid hormones. Accumulating evidence suggests interactions between obesity and sex in regulation of AD risk, although the pathways underlying this relationship are unclear. Inflammation and the E4 allele of apolipoprotein E have been identified as independent risk factors for AD and both interact with obesity and sex steroid hormones. We review the individual and cooperative effects of obesity and sex on development of AD and examine the potential contributions of apolipoprotein E, inflammation, and their interactions to this relationship. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free