Apolipoprotein E4, amyloid, and cognition in Alzheimer's and Lewy body disease

NEUROBIOLOGY OF AGING

卷:106

Article

Jung, Jin Ho¹  Jeon, Seun^2,6  Baik, Kyoungwon²  Lee, Yang Hyun²  Chung, Seok Jong^2,3  Yoo, Han Soo²  Jeong, Seong Ho⁴  Sohn, Young H.²  Lee, Phil Hyu^2,5  Ye, Byoung Seok² 

[1] Inje Univ, Coll Med, Busan Paik Hosp, Dept Neurol, Busan, South Korea

[2] Yonsei Univ, Coll Med, Dept Neurol, Seoul, South Korea

[3] Yonsei Univ Hlth Syst, Yongin Severance Hosp, Dept Neurol, Yongin, South Korea

[4] Inje Univ, Coll Med, Sanggye Paik Hosp, Dept Neurol, Seoul, South Korea

[5] Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea

[6] Yonsei Univ, Coll Med, Brain Res Inst, Seoul, South Korea

关键词: Apolipoprotein E;    Alzheimer's disease;    beta-amyloid;    Cognition;    Lewy body disease;    Mixed dementia;   

DOI  :  10.1016/j.neurobiolaging.2021.06.004

来源: Elsevier

【 摘 要 】

The role of apolipoprotein E4 (APOE4) in the risk of Alzheimer's disease (AD) and Lewy body disease (LBD), and their relationship with beta-amyloid deposition and cognitive dysfunction, remain unclear. Using amyloid and dopamine transporter imaging, we enrolled 126 controls and 208 patients with typical AD (pure AD and Lewy body variant of AD), AD with dementia with Lewy bodies, or typical LBD (dementia with Lewy bodies with amyloid deposition and pure LBD). APOE4 was associated with an increased risk of all disease subtypes except pure LBD. APOE4 was associated with increased frontal beta-amyloid burden, and typical LBD was associated with increased occipital beta-amyloid levels through its interaction with APOE4. APOE4 was associated with deteriorated general cognition and memory dysfunction via its interaction with typical LBD and AD, respectively. In conclusion, the impact of APOE4 on disease risk depends on its effects on beta-amyloid deposition, and APOE4 is associated with beta-amyloid deposition regardless of the clinical diagnosis. However, it interacts with typical LBD to cause occipital beta-amyloid deposition. (C) 2021 Elsevier Inc. All rights reserved.

【 授权许可】

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