Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:94

Review

Weissberger, Gali H.¹  Nation, Daniel A.²  Nguyen, Caroline P.¹  Bondi, Mark W.³  Han, Duke^1,2,4,5 

[1] USC Keck Sch Med, Dept Family Med, 1000 S Fremont Ave,Unit 22,HSA Bldg A-6,4thFloor, Alhambra, CA 91803 USA

[2] USC Dornsife Coll Letters Arts & Sci, Dept Psychol, Los Angeles, CA 90089 USA

[3] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr 9116-B, La Jolla, CA 92093 USA

[4] USC Sch Gerontol, Los Angeles, CA 90089 USA

[5] USC Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA

关键词: Apolipoprotein E;    Alzheimer's disease;    Cognition;    Neuropsychology;    Executive functions;    PRISMA;   

DOI  :  10.1016/j.neubiorev.2018.08.009

来源: Elsevier

【 摘 要 】

The apolipoprotein (APOE) epsilon 4 allele has been proposed as an example of an antagonistic pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental impact on cognition during later years. However, findings on the cognitive associations of the epsilon 4 allele in younger persons are mixed. This PRISMA conforming study aimed to investigate APOE genotype (e4/non-e4) associations across seven cognitive domains (intelligence/achievement, attention/working memory, executive functioning, memory, language, processing speed and visuospatial abilities) in younger humans using a meta-analytic approach. Of 689 records reviewed, 29 studies (34 data-points) were selected for the quantitative synthesis. Participants' ages ranged from 2-40. Results showed that young epsilon 4 carriers did not statistically differ from non-epsilon 4 carriers across any cognitive domains. Overall, findings do not provide compelling support for an antagonistic pleiotropic effect of the epsilon 4 allele across the lifespan.

【 授权许可】

Free