Dopamine modulation of spatial navigation memory in Parkinson's disease

NEUROBIOLOGY OF AGING

卷:38

Article

Thurm, Franka¹  Schuck, Nicolas W.²  Fauser, Mareike³  Doeller, Christian F.⁴  Stankevich, Yuliya⁵  Evens, Ricarda⁵  Riedel, Oliver^5,8  Storch, Alexander^3,6,9  Lueken, Ulrike^5,10  Li, Shu-Chen^1,7 

[1] Tech Univ Dresden, Dept Psychol, Chair Lifespan Dev Neurosci, D-01062 Dresden, Germany

[2] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA

[3] Tech Univ Dresden, Div Neurodegenerat Dis, Dept Neurol, Dresden, Germany

[4] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands

[5] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Dept Psychol, Dresden, Germany

[6] German Ctr Neurodegenerat Dis DZNE Dresden, Dresden, Germany

[7] Max Planck Inst Human Dev, Ctr Lifespan Psychol, Berlin, Germany

[8] Leibniz Inst Prevent Res & Epidemiol, Dept Clin Epidemiol, D-28359 Bremen, Germany

[9] Univ Rostock, Med Ctr, Dept Neurol, D-18147 Rostock, Germany

[10] Univ Hosp Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, D-97080 Wurzburg, Germany

关键词: Spatial navigation;    Striatum;    Hippocampus;    Parkinson's disease;    Dopamine;    Aging;   

DOI  :  10.1016/j.neurobiolaging.2015.10.019

来源: Elsevier

【 摘 要 】

Striatal dopamine depletion is a key pathophysiological feature of Parkinson's disease (PD) causing motor and nonmotor symptoms. Research on nonmotor symptoms has mainly focused on frontostriatal functions. However, dopamine pathways ascending from the ventral tegmental area also innervate hippocampal structures and modulate hippocampal-dependent functions, such as spatial memory. Using a virtual spatial navigation task, we investigated dopaminergic modulation of spatial memory in PD patients in a crossover medication ON/OFF design. We examined medication effects on striatal-and hippocampal-dependent spatial memory by either replacing a location cue in the environment or enlarging its spatial boundary. Key results indicate that in contrast to prior evidence for younger adults, PD patients, like their age-matched controls, rely more on striatal cue-based than hippocampal spatial learning. Medication facilitated striatal-dependent cue-location learning, whereas medication benefit in hippocampal boundary-related spatial memory depended on prior experience with the task. Medication effects on spatial memory were comparable to and independent of benefits on motor symptoms. These findings shed new light on dopaminergic modulation of hippocampal-striatal functions in PD. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free