NEUROBIOLOGY OF AGING | 卷:51 |
Exploring the contribution of spatial navigation to cognitive functioning in older adults | |
Article | |
Laczo, Jan1,2,3  Andel, Ross3,4  Nedelska, Zuzana1,2,3  Vyhnalek, Martin1,2,3  Vlcek, Kamil5  Crutch, Sebastian6  Harrison, John7,8  Hort, Jakub1,2,3  | |
[1] Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Prague, Czech Republic | |
[2] Motol Univ Hosp, V Uvalu 84, Prague 15006 5, Czech Republic | |
[3] St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic | |
[4] Univ S Florida, Sch Aging Studies, Tampa, FL USA | |
[5] Acad Sci Czech Republ, Inst Physiol, Vvi, Dept Neurophysiol Memory, Prague, Czech Republic | |
[6] UCL, UCL Inst Neurol, Dementia Res Ctr, London, England | |
[7] Metis Cognit Ltd, Kilmington, England | |
[8] Imperial Coll, Fac Med, London, England | |
关键词: Alzheimer's disease; Mild cognitive impairment; Morris Water Maze; Spatial navigation; Hippocampus; Neuropsychology; | |
DOI : 10.1016/j.neurobiolaging.2016.12.003 | |
来源: Elsevier | |
【 摘 要 】
Spatial navigation (SN) impairment is present early in Alzheimer's disease (AD). We tested whether SN performance, self-centered (egocentric) and world-centered (allocentric), was distinguishable from performance on established cognitive functions-verbal and nonverbal memory, executive and visuospatial function, attention/working memory, and language function. 108 older adults ( 53 cognitively normal [CN] and 55 with amnestic mild cognitive impairment [aMCI]) underwent neuropsychological examination and real-space navigation testing. Subset (n = 63) had automated hippocampal volumetry. In a factor analysis, allocentric and egocentric navigation tasks loaded highly onto the same factor with low loadings on other factors comprising other cognitive functions. In linear regression, performance on other cognitive functions was not, or was only marginally, associated with spatial navigation performance in CN or aMCI groups. After adjustment for age, gender, and education, right hippocampal volume explained 26% of the variance in allocentric navigation in aMCI group. In conclusion, spatial navigation, a known cognitive marker of early AD, may be distinguished from other cognitive functions. Therefore, its assessment along with other major cognitive functions may be highly beneficial in terms of obtaining a comprehensive neuropsychological profile. (C) 2016 Elsevier Inc. All rights reserved.
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