Foundations for in vivo nano-scale measurement of memory processes.

Forsythe, James Chris

Sandia National Laboratories

关键词: Experiment Planning Neurophysiology.;    Hippocampus;    Monitoring;    Technology Utilization;    Neurophysiology.;   

DOI  :  10.2172/966587
RP-ID  :  SAND2006-5703
RP-ID  :  AC04-94AL85000
RP-ID  :  966587

美国|英语

来源: UNT Digital Library

【 摘 要 】

An ongoing program of research and development is utilizing nanomaterials as a basis for observing and measuring neurophysiological processes. Work commencing in fiscal year 2007 will focus on expanding current capabilities to create nanoelectrode arrays that will allow nanoscale measurement of the activity of 10's to 100's of neurons. This development is a vital step in gaining scientific insights concerning network properties associated with neural representations and processes. Specifically, attention will be focused the representation of memory in the hippocampus, for which extensive research has been conducted using laboratory rats. This report summarizes background research providing a foundation for work planned for fiscal year 2007 and beyond. In particular, the neuroanatomy and neurophysiology of the hippocampus is described. Additionally, several programs of research are described that have addressed the relationship between neurophysiological processes and behavioral measures of memory performance. These studies provide insight into methodological and analytic approaches for studying the representation of memory processes in the hippocampus. The objective of this report is to document relevant literature in a reference document that will support future research in this area.