Multiplexed coding in the human basal ganglia

20th Argentinean Bioengineering Society Congress

物理学;生物科学

Andres, D.S.^1,2,3 ; Cerquetti, D.^3 ; Merello, M.^3

Institute of Neuroinformatics, ETH and University Zurich, Zurich, Switzerland^1

National University of San Martin, Buenos Aires, Argentina^2

Institute for Neurological Research Raul Carrea, Fleni Institute, Buenos Aires, Argentina^3

关键词: Basal ganglia;    Neural code;    Parkinson's disease;    Structure functions;    time patterns;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/705/1/012049/pdf
DOI  :  10.1088/1742-6596/705/1/012049

学科分类：生物科学（综合）

来源: IOP

【 摘 要 】

A classic controversy in neuroscience is whether information carried by spike trains is encoded by a time averaged measure (e.g. a rate code), or by complex time patterns (i.e. a time code). Here we apply a tool to quantitatively analyze the neural code. We make use of an algorithm based on the calculation of the temporal structure function, which permits to distinguish what scales of a signal are dominated by a complex temporal organization or a randomly generated process. In terms of the neural code, this kind of analysis makes it possible to detect temporal scales at which a time patterns coding scheme or alternatively a rate code are present. Additionally, finding the temporal scale at which the correlation between interspike intervals fades, the length of the basic information unit of the code can be established, and hence the word length of the code can be found. We apply this algorithm to neuronal recordings obtained from the Globus Pallidus pars interna from a human patient with Parkinson's disease, and show that a time pattern coding and a rate coding scheme co-exist at different temporal scales, offering a new example of multiplexed neuronal coding.