Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females

NEUROBIOLOGY OF AGING

卷:105

Article

Edwards, Lauren¹  La Joie, Renaud¹  Iaccarino, Leonardo¹  Strom, Amelia¹  Baker, Suzanne L.²  Casaletto, Kaitlin B.¹  Cobigo, Yann¹  Grant, Harli¹  Kim, Minseon¹  Kramer, Joel H.¹  Mellinger, Taylor J.¹  Pham, Julie¹  Possin, Katherine L.¹  Rosen, Howard J.¹  Soleimani-Meigooni, David N.¹  Wolf, Amy¹  Miller, Bruce L.¹  Rabinovici, Gil D.^1,2,3,4 

[1] Univ Calif San Francisco, Memory & Aging Ctr, Weill Inst Neurosci, Dept Neurol, San Francisco, CA 94158 USA

[2] Lawrence Berkeley Natl Lab, Life Sci Div, Berkeley, CA USA

[3] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[4] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94158 USA

关键词: Alzheimer's disease;    Sex differences;    Positron emission tomography;    Amyloid;    Tau;    Apolipoprotein E;   

DOI  :  10.1016/j.neurobiolaging.2021.04.003

来源: Elsevier

【 摘 要 】

We assessed sex differences in amyloid- and tau-PET retention in 119 amyloid positive patients with mild cognitive impairment or Alzheimer's disease (AD) dementia. Patients underwent 3T-MRI, C-11-PIB amyloid-PET and F-18-Flortaucipir tau-PET. Linear ordinary least squares regression models tested sex differences in Flortaucipir-PET SUVR in a summary temporal region of interest as well as global PIB-PET. No sex differences were observed in demographics, Clinical Dementia Rating Sum of Boxes (CDR-SoB), Mini-Mental State Exam (MMSE), raw episodic memory scores, or cortical thickness. Females had higher global PIB SUVR (eta(2)(p)=.043, p=.025) and temporal Flortaucipir SUVR (eta(2)(p) =.070, p=.004), adjusting for age and CDR-SoB. Sex differences in temporal Flortaucipir-PET remained significant when controlling additionally for PIB SUVR and APOE4 status (eta(2)(p)=.055, p=.013), or when using partial volume-corrected data. No sex differences were present in areas of known Flortaucipir off-target binding. Overall, females demonstrated greater AD regional tau-PET burden than males despite clinical comparability. Further characterization of sex differences will provide insight into AD pathogenesis and support development of personalized therapeutic strategies. (C) 2021 Elsevier Inc. All rights reserved.

【 授权许可】

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