Benzodiazepine use and brain amyloid load in nondemented older individuals: a florbetapir PET study in the Multidomain Alzheimer Preventive Trial cohort

NEUROBIOLOGY OF AGING

卷:84

Article

Desmidt, Thomas^1,2  Lebouvier, Thibaud⁸  Robert, Gabriel^9,10  David, Renaud¹¹  Balageas, Anna-Chloe²  Surget, Alexandre¹  Belzung, Catherine¹  Arlicot, Nicolas^1,3,12  Ribeiro, Maria-Joao^1,2,3  Payoux, Pierre^6,7  Vellas, Bruno^4,5  El-Hage, Wissam^1,2,3  Tavernier, Elsa^2,3  Camus, Vincent^1,2  Delrieu, Julien^4,5 

[1] Univ Tours, INSERM, IBrain, UMR 1253, Tours, France

[2] CHU Tours, Tours, France

[3] Univ Tours, INSERM, CIC 1415, Tours, France

[4] CHU Toulouse, Purpan Univ Hosp, Gerontopole, Dept Geriatr, Toulouse, France

[5] Univ Toulouse, UPS, INSERM, UMR1027, Toulouse, France

[6] Univ Toulouse III, Toulouse Neuroimaging Ctr, UMR 1214, Toulouse, France

[7] CHU Toulouse, Univ Hosp Toulouse, Dept Nucl Med, Toulouse, France

[8] Univ Lille, CHU Lille, INSERM, U1171,DistalZ, Lille, France

[9] Univ Rennes 1, Behav & Basal Ganglia Host Team 4712, Rennes, France

[10] Rennes Univ Hosp, Guillaume Regnier Hosp Ctr, Dept Psychiat, Rennes, France

[11] CHU Nice, Memory Res & Resources Ctr, Dept Psychiat, Nice, France

[12] CHRU Tours, Unite Radiopharm, Tours, France

关键词: Benzodiazepine;    GABA-A;    Amyloid;    Florbetapir;    Positron emission tomography;    Alzheimer's disease;   

DOI  :  10.1016/j.neurobiolaging.2019.08.008

来源: Elsevier

【 摘 要 】

It remains unclear whether benzodiazepines (BZDs) constitute a risk factor for Alzheimer's disease (AD). In this study, we investigated associations between chronic use of BZDs and brain amyloid load, a hallmark of AD, in 268 nondemented older individuals. F-18-florbetapir positron emission tomography scans were performed to assess amyloid load as measured by standardized uptake value ratios, which were compared between chronic BZD users and nonusers using adjusted multiple linear regressions. Short- versus long-acting BZDs were also considered in the analyses. Standardized uptake value ratios were significantly lower in BZD users (n = 47) than in nonusers (n = 221), independent of multiple adjustments. The effect was stronger for short-acting BZDs than for long-acting BZDs. This is the first large clinical study showing a reduced brain amyloid load in chronic BZD users, especially with short-acting BZDs. Our results do not support the view of BZD use as a risk factor for AD and instead support the involvement of pharmacological mechanisms related to neuronal hyperactivity, neuroinflammation, and sleep quality as potential targets for blocking amyloid accumulation. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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