In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Simon Cervenka¹  Patricia Vázquez Rodríguez²  Luca Passamonti²  Tim D. Fryer²  Timothy Rittman²  Young T. Hong²  Franklin I. Aigbirhio²  John T. O'Brien³  Ajenthan Surendranathan³  Elijah Mak³  Richard W. Bevan‐Jones³  Robert Arnold³  Silvy Gabel³  Li Su³  Richard A.I. Bethlehem³  Rafael Romero‐Garcia³  James B. Rowe⁴  Guy B. Williams⁵ 

[1] Department of Clinical Neuroscience, Centre for Psychiatry ResearchKarolinska Institutet and Stockholm County CouncilStockholmSweden;Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK;Department of PsychiatryUniversity of CambridgeCambridgeUK;Medical Research Council, and Brain Sciences UnitCambridgeUK;Wolfson Brain Imaging CentreUniversity of CambridgeCambridgeUK;

关键词: Alzheimer's disease;    Tau;    Amyloid;    Positron emission tomography;    Atrophy;    Cortical thickness;   

DOI  :  10.1016/j.dadm.2018.08.005

来源: DOAJ

【 摘 要 】

Abstract Introduction The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear. Methods We estimated cortical thickness, tau ([18F]‐AV‐1451), and amyloid β (Aβ) status ([11C]‐PiB) in 47 subjects who were stratified into Aβ− (14 healthy controls and six mild cognitive impairment–Aβ−) and Aβ+ (14 mild cognitive impairment–Aβ+ and 13 AD) groups. Results Compared with the Aβ− group, tau was increased in widespread regions whereas cortical thinning was restricted to the temporal cortices. Increased tau binding was associated with cortical thinning in each Aβ group. Locally, regional tau was associated with temporoparietal atrophy. Discussion These findings position tau as a promising therapeutic target. Further studies are needed to elucidate the casual relationships between tau pathology and trajectories of atrophy in AD.

【 授权许可】

Unknown