Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

NEUROBIOLOGY OF AGING

卷:35

Article

Baik, Sung Hoon¹  Cha, Moon-Yong¹  Hyun, Young-Min²  Cho, Hansang⁴  Hamza, Bashar⁴  Kim, Dong Kyu¹  Han, Sun-Ho¹  Choi, Heesun¹  Kim, Kyung Ho¹  Moon, Minho¹  Lee, Jeewoo³  Kim, Minsoo^1,2  Irimia, Daniel⁴  Mook-Jung, Inhee¹ 

[1] Seoul Natl Univ, Coll Med, Dept Biochem & Biomed Sci, Seoul 110799, South Korea

[2] Univ Rochester, David H Smith Ctr Vaccine Biol & Immunol, Dept Microbiol & Immunol, Rochester, NY USA

[3] Seoul Natl Univ, Coll Pharm, Dept Pharmacol, Seoul, South Korea

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, BioMEMS Resource Ctr, Boston, MA USA

关键词: Alzheimer's disease;    Neutrophils;    Amyloid plaques;    Immune cells;   

DOI  :  10.1016/j.neurobiolaging.2014.01.003

来源: Elsevier

【 摘 要 】

Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free