Secretion of Cytokines and Chemokines by Innate Immune Cells

Frontiers Research Topics

Paige Lacy

keywords: Macrophages;    Neutrophils;    Eosinophils;    Dendritic Cells;    Epithelial Cells;    degranulation;    SNAREs;    GTPases;    Recycling endosomes;    secretory granules;   

Publisher: Frontiers Media SA

Subject:

【 摘 要 】

The release of cytokines, chemokines, and other immune-modulating mediators released from innate immune cells, including eosinophils, neutrophils, macrophages, dendritic cells, mast cells, and epithelial cells, is an important event in immunity. Cytokine synthesis and transportation occurs through the canonical protein trafficking pathway associated with endoplasmic reticulum and Golgi. How cytokines are released upon their exit from the trans-Golgi network varies enormously between cell types, and in many cells this has not yet been characterized. This issue delves into the plethora of cytokines released by innate immune cells, and where possible, shines light on specific mechanisms that regulate trafficking and release of Golgi-derived vesicles. Each cell type also shows varying degrees of dependency on microtubule organization and actin cytoskeleton remodeling for cytokine secretion. Understanding the mechanisms of cytokine secretion will reveal the inner workings of individual innate immune cell types, and allow identification of critical regulatory steps in cytokine release.

【 授权许可】

CC BY   
Copyright 2007-2040 Frontiers Media SA. All rights reserved. All content included on this site, such as text, graphics, logos, button icons, images, video/audio clips, downloads, data compilations and software, is the property of or is licensed to.All copyright, and all rights therein, are protected by national and internation.The above represents a summary only. For the full conditions see the Conditions for Authors and the Conditions for Website Use.

【 图 表 】

Secretion of Cytokines and Chemokines by Innate Immune Cells.PDF

Secretion of Cytokines and Chemokines by Innate Immune Cells.jpg