Biotherapeutic mechanism of salidroside on gastric carcinoma cells

International Conference on Manufacturing Technology, Materials and Chemical Engineering

材料科学;化学工业

Wang, Xiaoping^1 ; Wang, Qiaoxia^2 ; Lin, Huanping^1 ; Xu, Bing^1 ; Chang, Na^1 ; Chao, Xu^1 ; Shi, Hailong^1 ; Meng, Bobo^1

Laboratory of Molecular Pathology, Shaanxi University of Chinese Medicine, Xianyang, China^1

Department of Infectious Diseases, Xi'An Central Hospital, Xi'an, China^2

关键词: Antitumor effect;    Cytotoxic T lymphocytes;    Experimental groups;    Gastric cancers;    Gastric carcinoma;    Immune cells;    Research models;    Tumor volumes;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/592/1/012016/pdf
DOI  :  10.1088/1757-899X/592/1/012016

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

To study the biotherapy mechanisms of salidroside in treatment of gastric carcinoma, we inoculated the BALB/C mice with a gastric carcinoma cell line as the research model. The mice were divided into four groups. Mice in the experimental groups received different doses of salidroside for sixty days after grafting. Mice were fed with normal saline as control. All the mice were executed at the 61st day. Tumor volume was detected periodically and tumor weight was measured immediately after the mice sacrificed. Serum cytokines, perforin and granzyme B were detected by ELISA. The anti-tumor effect was examined by cytotoxic T lymphocyte (CTL) method. Our results demonstrated that salidroside could suppress the proliferation of gastric carcinoma cells by activating the immune cells and inducing the secretion of cytokines, perforin and granzyme B. Our study suggests that salidroside inhibited the growth of gastric cancers by activating the immune cells, which may lay a better basis for further study on gastric cancer biotherapy.