Adaptive immune response in residents of the Russian Arctic zone and South Ossetia

4th International Scientific Conference "Arctic: History and Modernity"

生态环境科学;历史学

Kabbani, M.S.^1 ; Shchegoleva, L.S.^1^2

Northern (Arctic) Federal University Named after M.V. Lomonosov, Arkhangelsk, Russia^1

Federal Center for Integrated Arctic Research, Russ. Acad. of Sci. of Natural Adaptation Physiology Institute Named after Academician N.P. Laverov, Arkhangelsk, Russia^2

关键词: Adaptive immune response;    Cytotoxic T lymphocytes;    Environmental factors;    Functional systems;    Immune response;    Living conditions;    Lymphoid cells;    Protective function;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/302/1/012076/pdf
DOI  :  10.1088/1755-1315/302/1/012076

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

The human body in adverse living conditions, such as in the Arctic, goes through the risk of impairing functional systems including the immune system. These disturbances lead to appear states of weakness or hyperactivity of the organism protective function. This study investigates the state of the adaptive immune response of 40-60-year-old women living in the Russian Arctic and South Ossetia. The indirect immunoperoxidase assay with monoclonal antibodies was used to analyze the immune parameters of lymphoid subpopulations in 40-60-year-old women living in Nadym city in the Yamalo-Nenets Autonomous Okrug and in Tskhinval city in South Ossetia. After analyzing the received data, the deficiency of mature T-lymphocytes (CD3+) was found in 96-100% of the examined individuals. We also revealed a decrease in the concentration of T-helper (CD4+) and B-activated (HLA-DR+) cells in 30% of Arctic zone cases and in 50% of the southern zone cases on the background of increasing concentrations of cytotoxic T-lymphocytes. A deficiency of cells with apoptosis receptors (CD95+) was registered mainly in Tskhinval women (80%). Thus, it can be assumed that the deficiency of mature lymphoid cells with a receptor (CD3+) leads to disruption of the T-cell pool of the immune response and delay of the adaptive immune response overall. The increase in the cytotoxic T-lymphocyte count indicates the stress state of the adaptive immune component to compensate for the lack of T-helper and B-activated cells concentration. Additional comprehensive studies are needed to identify environmental factors having a significant impact on the mechanism of the adaptive immune response development.