Differentiated T-Cells Ratio in the Immune Response in Residents of Arctic and Middle Zone of the Russian Federation

Arctic Biomonitoring

Kabbani, M.S.^1 ; Shchegoleva, L.S.^1^2

Northern (Arctic) Federal University, Arkhangelsk, Russia^1

Russian Academy of Sciences' N.P. Laverov Institute of Natural Adaptation Physiology, Federal Center for Integrated Arctic Research, Arkhangelsk, Russia^2

关键词: Cell populations;    Cytotoxic T lymphocytes;    Immune disorders;    Immune response;    Natural killer cells;    Reserve capacity;    Russian federation;    Short periods;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/263/1/012031/pdf
DOI  :  10.1088/1755-1315/263/1/012031

来源: IOP

【 摘 要 】

The climate and environment of the northern and central regions of Russia have a significant impact on human health and, particularly, immune system, especially in women. Exposed to adverse conditions, the immune status is characterized by a short period of resistance, deficiency of T-cell population, weakened reserve capacity of immune homeostasis, and increased incidence of immune disorders. A study has been conducted to identify the ratio of differentiated T-cells in the immune response in healthy, working women aged 40-60, residing in the settlement of Pinega (Arkhangelsk Region) and the city of Vologda. The study has revealed leukopenia in 35.5% of Pinega women and lymphopenia in 31.8% of Vologda women. Regardless of the area of residence, 94.0% of the surveyed have deficit of mature T-lymphocytes (CD3+). The deficit of T-helper cells (CD4+) is suffered by 34.1% of Vologda women and 22.2% of Pinega ones. Furthermore, an increased content of cytotoxic T-lymphocytes and natural killer cells was detected in approximately 66% of Vologda and Pinega women.