Brain regional synchronous activity predicts tauopathy in 3 x TgAD mice

NEUROBIOLOGY OF AGING

卷:70

Article

Liu, Dong¹  Lu, Hanbing²  Stein, Elliot²  Zhou, Zhujuan³  Yang, Yihong²  Mattson, Mark P.^1,4 

[1] NIA, Lab Neurosci, Intramural Res Program, Baltimore, MD 21224 USA

[2] NIDA, Neuroimaging Res Branch, Intramural Res Program, Baltimore, MD USA

[3] Army Med Univ, Xinqiao Hosp, Dept Neurol, Chongqing, Peoples R China

[4] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

关键词: Alzheimer's disease;    Functional MRI;    Hyperexcitability;    Hippocampus;    Tau;    Amyloid beta peptide;   

DOI  :  10.1016/j.neurobiolaging.2018.06.016

来源: Elsevier

【 摘 要 】

Alzheimer's disease (AD) is characterized by progressive cognitive impairment and by extensive neuronal loss associated with extracellular amyloid beta-peptide (A beta) plaques and intraneuronal tau pathology in temporal and parietal lobes. AD patients are at increased risk for epileptic seizures, and data from experimental models of AD suggest that aberrant neuronal network activity occurs early in the disease process before cognitive deficits and neuronal degeneration. The contributions of A beta and/or tau pathologies to dysregulation of neuronal network activity are unclear. Using a transgenic mouse model of AD (3 x TgAD mice) in which there occurs differential age-dependent development of tau and Ab plaque pathologies, we applied analysis of resting state functional magnetic resonance imaging regional homogeneity, a measure of local synchronous activity, to discriminate the effects of Ab and tau on neuronal network activity throughout the brain. Compared to age-matched wild-type mice, 6- to 8-month-old 3 x TgAD mice exhibited increased regional homogeneity in the hippocampus and parietal and temporal cortices, regions with tau pathology but not A beta pathology at this age. By 18-24 months of age, 3 x TgAD mice exhibited extensive tau and A beta pathologies involving the hippocampus and multiple functionally related brain regions, with a spatial expansion of increased local synchronous activity to include those regions. Our findings demonstrate that age-related brain regional hypersynchronous activity is associated with early tau pathology in a mouse model, consistent with a role for early tau pathology in the neuronal circuit hyperexcitability that is believed to precede and contribute to neuronal degeneration in AD. Published by Elsevier Inc.

【 授权许可】

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