Amyloid burden and neural function in people at risk for Alzheimer's Disease

NEUROBIOLOGY OF AGING

卷:35

Article

Johnson, Sterling C.^1,2,3  Christian, Bradley T.^2,4  Okonkwo, Ozioma C.^1,2  Oh, Jennifer M.^1,2  Harding, Sandra^1,2  Xu, Guofan^2,5  Hillmer, Ansel T.⁴  Wooten, Dustin W.⁴  Murali, Dhanabalan⁴  Barnhart, Todd E.⁴  Hall, Lance T.⁵  Racine, Annie M.²  Klunk, William E.⁷  Mathis, Chester A.⁸  Bendlin, Barbara B.^1,2  Gallagher, Catherine L.^1,2  Carlsson, Cynthia M.^1,2  Rowley, Howard A.^2,5  Hermann, Bruce P.^2,3  Dowling, N. Maritza^1,2,6  Asthana, Sanjay^1,2,3  Sager, Mark A.^1,2,3 

[1] Wm S Middleton Mem VA Hosp, Geriatr Res Educ & Clin Ctr, Madison, WI USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Alzheimers Dis Res Ctr, Madison, WI USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Alzheimers Inst, Madison, WI USA

[4] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Phys, Madison, WI USA

[5] Univ Wisconsin, Sch Med & Publ Hlth, Dept Radiol, Madison, WI USA

[6] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI USA

[7] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[8] Univ Pittsburgh, Sch Med, Dept Radiol, Pittsburgh, PA USA

关键词: Alzheimer's disease;    Amyloid imaging;    Cognitive function;    Glucose metabolism;    AD risk;   

DOI  :  10.1016/j.neurobiolaging.2013.09.028

来源: Elsevier

【 摘 要 】

To determine the relationship between amyloid burden and neural function in healthy adults at risk for Alzheimer's Disease (AD), we used multimodal imaging with [C-11]Pittsburgh compound B positron emission tomography, [F-18]fluorodeoxyglucose, positron emission tomography, and magnetic resonance imaging, together with cognitive measurement in 201 subjects (mean age, 60.1 years; range, 46 -73 years) from the Wisconsin Registry for Alzheimer's Prevention. Using a qualitative rating, 18% of the samples were strongly positive Beta-amyloid (A beta+), 41% indeterminate (A beta i), and 41% negative (A beta-). A beta+ was associated with older age, female sex, and showed trends for maternal family history of AD and APOE4. Relative to the A beta group, A beta(vertical bar) and A beta i participants had increased glucose metabolism in the bilateral thalamus; A beta+ participants also had increased metabolism in the bilateral superior temporal gyrus. A beta+ participants exhibited increased gray matter in the lateral parietal lobe bilaterally relative to the A beta- group, and no areas of significant atrophy. Cognitive performance and self report cognitive and affective symptoms did not differ between groups. Amyloid burden can be identified in adults at a mean age of 60 years and is accompanied by glucometabolic increases in specific areas, but not atrophy or cognitive loss. This asymptomatic stage may be an opportune window for intervention to prevent progression to symptomatic AD. Published by Elsevier Inc.

【 授权许可】

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