Joint associations of β-amyloidosis and cortical thickness with cognition

NEUROBIOLOGY OF AGING

卷:65

Article

Knopman, David S.^1,2  Lundt, Emily S.³  Therneau, Terry M.³  Vemuri, Prashanthi^2,4  Lowe, Val J.^2,4  Kantarci, Kejal^2,4  Gunter, Jeffrey L.^4,5  Senjem, Matthew L.^4,5  Mielke, Michelle M.^1,6  Machulda, Mary M.^2,7  Roberts, Rosebud O.^1,6  Boeve, Bradley F.^1,2  Jones, David T.^1,2,4  Petersen, Ronald C.^1,2,6  Jack, Clifford R., Jr.^2,4 

[1] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN USA

[2] Mayo Clin & Mayo Fdn, Mayo Clin, Alzheimers Dis Res Ctr, Rochester, MN USA

[3] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA

[4] Mayo Clin & Mayo Fdn, Dept Radiol, Rochester, MN USA

[5] Mayo Clin & Mayo Fdn, Dept Informat Technol, Rochester, MN USA

[6] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Div Epidemiol, Rochester, MN USA

[7] Mayo Clin & Mayo Fdn, Dept Psychiat, Div Psychol, Rochester, MN USA

关键词: Amyloid imaging;    Neurodegeneration biomarkers;    Structural MR imaging;    Cognitive aging;    Alzheimer's disease;   

DOI  :  10.1016/j.neurobiolaging.2018.01.017

来源: Elsevier

【 摘 要 】

In 1164 cognitively unimpaired persons, aged 50-95 years, from the population-based Mayo Clinic Study of Aging, we examined the relationships of baseline cognition and cognitive changes across the full range of cortical thickness of an Alzheimer signature region of interest and global beta-amyloid levels measured by Pittsburgh compound B positron emission tomography (PIB PET) standardized uptake value ratio (SUVR). In machine-learning models accounting for both biomarkers simultaneously, worsening biomarker values were additive and associated with lower baseline global cognition and greater subsequent decline in global cognition. Associations between Alzheimer's disease signature cortical thickness or PIB PET beta-amyloid SUVR and baseline cognition were mainly linear. Lower Alzheimer's disease signature cortical thickness values across the entire range of thickness predicted future decline in global cognitive scores, demonstrating its close relationship to cognitive functioning. PIB PET beta-amyloid SUVR also predicted cognitive decline across its full range, even when cortical thickness was accounted for. PIB PET beta-amyloid's relationship to cognitive decline was nonlinear, more prominent at lower beta-amyloid levels and less prominent at higher beta-amyloid levels. (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

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