Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer’s disease

Alzheimer’s Research & Therapy

Victor L. Villemagne¹  Vincent Doré¹  Paul A. Yates¹  Sanka Amadoru¹  Christopher C. Rowe¹  Claire E. Shepherd²  Glenda M. Halliday²  Cristian E. Leyton³  John R. Hodges³  Fairlie Hinton⁴  Catriona A. McLean⁴  Colin L. Masters⁴ 

[1] Department of Molecular Imaging and Therapy, Austin Health;Sydney Brain Bank, Neuroscience Research Australia and Faculty of Medicine, University of NSW;The Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney;Victorian Brain Bank, The Florey Institute of Neuroscience and Mental Health;

关键词: Amyloid imaging;    Alzheimer’s disease;    Centiloids;    Positron emission tomography;    Neuropathology;   

DOI  :  10.1186/s13195-020-00587-5

来源: DOAJ

【 摘 要 】

Abstract Background The Centiloid scale was developed to standardise the results of beta-amyloid (Aβ) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer’s disease neuropathologic change (ADNC) score of intermediate or high probability of Alzheimer’s Disease (AD), final clinicopathological diagnosis of AD, and expert visual read of a positive Aβ PET scan. Methods Aβ PET results in CL for 49 subjects were compared with post-mortem findings, visual read, and final clinicopathological diagnosis. The Youden Index was used to determine the optimal CL thresholds from receiver operator characteristic (ROC) curves. Results A threshold of 20.1 CL (21.3 CL when corrected for time to death, AUC 0.97) yielded highest accuracy in detecting moderate or frequent plaque density while < 10 CL was optimal for excluding neuritic plaque. The threshold for ADNC intermediate or high likelihood AD was 49.4 CL (AUC 0.98). Those cases with a final clinicopathological diagnosis of AD yielded a median CL result of 87.7 (IQR ± 42.2) with 94% > 45 CL. Positive visual read agreed highly with results > 26 CL. Conclusions Centiloid values < 10 accurately reflected the absence of any neuritic plaque and > 20 CL indicated the presence of at least moderate plaque density, but approximately 50 CL or more best confirmed both neuropathological and clinicopathological diagnosis of Alzheimer’s disease.

【 授权许可】

Unknown