Age-associated cerebral atrophy in mouse lemur primates

NEUROBIOLOGY OF AGING

卷:32

Article

Kraska, Audrey^1,2  Dorieux, Olene^1,2,3  Picq, Jean-Luc^3,4  Petit, Fanny^1,2  Bourrin, Emmanuel^1,2,5  Chenu, Evelyne⁶  Volk, Andreas⁶  Perret, Martine³  Hantraye, Philippe^1,2  Mestre-Frances, Nadine⁷  Aujard, Fabienne³  Dhenain, Marc^1,2,8 

[1] CEA, CNRS, URA 2210, F-92265 Fontenay Aux Roses, France

[2] CEA, DSV, I2BM, MIRCen, F-92265 Fontenay Aux Roses, France

[3] CNRS, UMR 7179, MNHN, F-91800 Brunoy, France

[4] Univ Paris 08, Lab Psychopathol & Neuropsychol, EA 2027, F-93000 St Denis, France

[5] Inst Rech Servier, F-78290 Croissy Sur Seine, France

[6] Ctr Univ Orsay, Inst Curie, INSERM, U759, F-91405 Orsay, France

[7] Univ Montpellier 2, INSERM, U710, EPHE, F-34095 Montpellier 5, France

[8] Ctr CEA Saclay, CEA, DSV, I2BM, F-91191 Gif Sur Yvette, France

关键词: Alzheimer's disease;    Amyloid;    Animal models;    Atrophy;    MRI;    Tau;   

DOI  :  10.1016/j.neurobiolaging.2009.05.018

来源: Elsevier

【 摘 要 】

We assessed the regional brain atrophy in mouse lemur primates from 4.7 T T2-weighted magnetic resonance images. Thirty animals aged from 1.9 to 11.3 years were imaged. Sixty-one percent of the 23 animals older than 3 years involved in the study displayed an atrophy process. Cross-sectional analysis suggests that the atrophy follows a gradual pathway, starting in the frontal region then involving the temporal and/or the parietal part of the brain and finally the occipital region. Histological evaluation of five animals selected according to various stages of atrophy suggested that extracellular amyloid deposits and tau pathology cannot explain by themselves this atrophy and that intracellular amyloid deposition is more closely linked to this pathology. This study suggests that most of the age-related atrophy occurring in mouse lemurs is caused by one clinical, evolving, pathological process. The ability to follow this pathology non-invasively by MRI will allow to further characterize it and evaluate its relationship with neuropathological lesions that are involved in human diseases such as Alzheimer. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

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