Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia

PSYCHIATRY RESEARCH

卷:188

Article

Brown, Alan S.^1,2  Vinogradov, Sophia³  Kremen, William S.⁴  Poole, John H.⁵  Bao, Yuanyuan¹  Kern, David¹  McKeague, Ian W.⁶ 

[1] Columbia Univ Coll Phys & Surg, New York State Psychiat Inst, Dept Psychiat, New York, NY 10032 USA

[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[4] Univ Calif San Diego, Dept Psychiat, Ctr Behav Genom, San Diego, CA 92103 USA

[5] Vet Hlth Care Syst, Def & Vet Brain Injury Ctr, Dept Neuropsychol, Palo Alto, CA USA

[6] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA

关键词: Infection;    Cognition;    Epidemiology;    Risk factors;    Environment;    Exposure;    Neurodevelopment;   

DOI  :  10.1016/j.psychres.2011.04.020

来源: Elsevier

【 摘 要 】

Maternal exposure to genital and reproductive infections has been associated with schizophrenia in previous studies. Impairments in several neuropsychological functions, including verbal memory, working memory, executive function, and fine-motor coordination occur prominently in patients with schizophrenia. The etiologies of these deficits, however, remain largely unknown. We aimed to assess whether prospectively documented maternal exposure to genital/reproductive (G/R) infections was related to these neuropsychological deficits in offspring with schizophrenia and other schizophrenia spectrum disorders. The cases were derived from a population-based birth cohort; all cohort members belonged to a prepaid health plan. Cases were assessed for verbal memory, working memory, executive function, and fine-motor coordination. Compared to unexposed cases, patients exposed to maternal genital/reproductive infection performed more poorly on verbal memory, fine-motor coordination, and working memory. Stratification by race revealed associations between maternal G/R infection and verbal memory and fine-motor coordination for case offspring of African-American mothers, but not for case offspring of White mothers. Significant infection-by-race interactions were also observed. Although independent replications are warranted, maternal G/R infections were associated with verbal memory and motor function deficits in African-American patients with schizophrenia. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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