Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution

Sao Paulo Medical Journal

Kelli Borges Santos²  Abrahão Elias Hallack Neto²  Girlene Alves Silva²  Angelo Atalla²  Marcus Matta Abreu¹  Luiz Cláudio Ribeiro² 

[1] ,Universidade Federal de Juiz de ForaJuiz de Fora Minas Gerais ,Brazil

关键词: Hematopoietic stem cell transplantation;    Transplantation;    autologous;    Infection;    Risk factors;    Infection control;    Transplante de células-tronco hematopoéticas;    Transplante autólogo;    Infecção;    Fatores de risco;    Controle de infecções;   

DOI  :  10.1590/S1516-31802012000100003

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: Hematopoietic stem cell transplantation (HSCT) has been widely used for treating oncological and hematological diseases. Although HSCT has helped to improve patient survival, the risk of developing infection during hospitalization is an important cause of morbidity and mortality. This study aimed to analyze the infection profile during hospitalization and the associated risk factors among patients undergoing autologous HSCT at the University Hospital, Universidade Federal de Juiz de Fora. DESIGN AND SETTING: This was a cross-sectional study on patients undergoing autologous HSCT at a public university hospital. METHODS: Patients with febrile neutropenia between 2004 and 2009 were retrospectively evaluated regarding their infection profile and associated risk factors. RESULTS: Infection occurred in 57.2% of 112 patients with febrile neutropenia. The main source of infection was the central venous catheter (25.9%). Infection was chiefly due to Gram-positive bacteria, although Gram-negative-related infections were more severe and caused a higher death rate. Sex, age, skin color, nutritional status and underlying disease were not associated with the development of infection. Patients with severe mucositis (Grades III and IV) had a higher infection rate (P < 0.001). Patients who developed pulmonary complications during hospitalization had higher infection rates (P = 0.002). Infection was the main cause of death (57.1%) in the study sample. CONCLUSION: Strategies aimed at reducing infection-related mortality rates among patients undergoing autologous HSCT are necessary.

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