NEUROBIOLOGY OF AGING | 卷:36 |
Periodontal disease associates with higher brain amyloid load in normal elderly | |
Article | |
Kamer, Angela R.1,2  Pirraglia, Elizabeth2  Tsui, Wai2  Rusinek, Henry2,3  Vallabhajosula, Shankar4  Mosconi, Lisa2  Yi, Li2  McHugh, Pauline2  Craig, Ronald G.1,5  Svetcov, Spencer1  Linker, Ross1  Shi, Chen1  Glodzik, Lidia2  Williams, Schantel2  Corby, Patricia1,6  Saxena, Deepak5  de Leon, Mony J.2  | |
[1] NYU, Coll Dent, Dept Periodontol & Implant Dent, New York, NY 10010 USA | |
[2] Ctr Brain Hlth, Sch Med, Dept Psychiat, New York, NY USA | |
[3] Sch Med, Dept Radiol, New York, NY USA | |
[4] Cornell Univ, Weill Med Ctr, Dept Radiol, New York, NY 10021 USA | |
[5] NYU, Coll Dent, Dept Basic Sci & Craniofacial Biol, New York, NY 10010 USA | |
[6] NYU, Coll Dent, Bluestone Ctr Clin Res, New York, NY 10010 USA | |
关键词: Alzheimer's disease; Infection; Inflammation; Periodontal disease; Brain amyloid; PIB-PET; Cognition; | |
DOI : 10.1016/j.neurobiolaging.2014.10.038 | |
来源: Elsevier | |
【 摘 要 】
The accumulation of amyloid-beta (A beta) plaques is a central feature of Alzheimer's disease (AD). First reported in animal models, it remains uncertain if peripheral inflammatory and/or infectious conditions in humans can promote A beta brain accumulation. Periodontal disease, a common chronic infection, has been previously reported to be associated with AD. Thirty-eight cognitively normal, healthy, and community-residing elderly (mean age, 61 and 68% female) were examined in an Alzheimer's Disease Research Center and a University-Based Dental School. Linear regression models (adjusted for age, apolipoprotein E, and smoking) were used to test the hypothesis that periodontal disease assessed by clinical attachment loss was associated with brain A beta load using C-11-Pittsburgh compound B (PIB) positron emission tomography imaging. After adjusting for confounders, clinical attachment loss (>= 3 mm), representing a history of periodontal inflammatory/infectious burden, was associated with increased PIB uptake in A beta vulnerable brain regions (p = 0.002). We show for the first time in humans an association between periodontal disease and brain A beta load. These data are consistent with the previous animal studies showing that peripheral inflammation/infections are sufficient to produce brain A beta accumulations. (C) 2015 Elsevier Inc. All rights reserved.
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