Ca2+-mediated coupling between neuromuscular junction and mitochondria in skeletal muscle

NEUROSCIENCE LETTERS

卷:754

Article

Zhou, Jingsong¹ 

[1] Univ Texas Arlington, Dept Kinesiol, Coll Nursing & Hlth Innovat, Arlington, TX 76010 USA

关键词: Skeletal muscle;    Neuromuscular junction;    Mitochondria;    Ca2+ signaling;   

DOI  :  10.1016/j.neulet.2021.135899

来源: Elsevier

【 摘 要 】

The volitional movement of skeletal is controlled by the motor neuron at the site of neuromuscular junction (NMJ) where the retrograde signals are also passed back from muscle to the motor neuron. As the normal function of muscle largely depends on mitochondria that determine the fate of a skeletal muscle myofiber, there must exist a fine-controlled functional coupling between NMJ and mitochondria in myofibers. This mini-review discusses recent publications that reveal how spatiotemporal profiles of intracellular free Ca2+ could couple mitochondrial function with the activity of NMJ in skeletal muscle myofibers.

【 授权许可】

Free