Curcumin Potentially to Increase Athlete Performance Through Regulated Mitochondrial Biogenesis

1st Annual Applied Science and Engineering Conference

工业技术;自然科学

Hamidie, R.D.R.^1,2 ; Masuda, K.^2

Department of Sport Science, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Indonesia^1

Faculty of Human Sciences, Kanazawa University, Japan^2

关键词: Curcuma longa l;    Endurance exercise;    Exercise training;    Glucose transporter 4;    Metabolic characteristics;    Mitochondrial biogenesis;    Second messenger;    Skeletal muscle;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/180/1/012202/pdf
DOI  :  10.1088/1757-899X/180/1/012202

来源: IOP

【 摘 要 】

A marked example of muscle adaptations occurs in the mitochondria following exercise training. Endurance training has potential to enhance metabolic characteristics in the skeletal muscle, including mitochondrial biogenesis and glucose transporter 4 (GLUT4). Polyphenol have been shown to activate cAMP, therefore, currently being intensively investigated as potential inducer of mitochondrial biogenesis through the deacetylation-mediated activation of PGC-1α. The polyphenol curcumin is components of curcuma longa L, have ability to regulated mitochondria biogenesis on skeletal muscle will review in this chapter. The examination the effect of combination of endurance training and curcumin treatment to increase mitochondrial biogenesis seem look like through AMPK, SIRT1 and PGC-1α pathway. Furthermore, in this review we also explained the direct target how curcumin treatment increase mitochondrial biogenesis. We focus on the second messenger cAMP which involve to regulated mitochondrial biogenesis. Indeed, previous study indicated that cAMP be the important target on endurance exercise training to increase mitochondrial biogenesis. The last, the current review determined how curcumin have ability to increase mitochondrial biogenesis on skeletal muscle with examine phosphorylation of PDE4A which involve to convert cAMP to AMP. Based on our previous experiments we conclude that indeed curcumin treatment have ability to increase performance through regulated mitochondria biogenesis on skeletal muscle.