Transgenic models of Alzheimer's disease: Better utilization of existing models through viral transgenesis

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1832

Review

Platt, Thomas L.^1,2  Reeves, Valerie L.²  Murphy, M. Paul^1,2 

[1] Univ Kentucky, Dept Cellular & Mol Biochem, Lexington, KY 40536 USA

[2] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

关键词: Alzheimer's disease;    Neurodegeneration;    Transgenic mouse model;    Adeno-associated virus;    Lentivirus;   

DOI  :  10.1016/j.bbadis.2013.04.017

来源: Elsevier

【 摘 要 】

Animal models have been used for decades in the Alzheimer's disease (AD) research field and have been crucial for the advancement of our understanding of the disease. Most models are based on familial AD mutations of genes involved in the amyloidogenic process, such as the amyloid precursor protein (APP) and presenilin 1 (PSI). Some models also incorporate mutations in tau (MAPT) known to cause frontotemporal dementia, a neurodegenerative disease that shares some elements of neuropathology with AD. While these models are complex, they fail to display pathology that perfectly recapitulates that of the human disease. Unfortunately, this level of pre-existing complexity creates a barrier to the further modification and improvement of these models. However, as the efficacy and safety of viral vectors improves, their use as an alternative to germline genetic modification is becoming a widely used research tool. In this review we discuss how this approach can be used to better utilize common mouse models in AD research. This article is part of a Special Issue entitled: Animal Models of Disease. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

Free