Implantable optical-electrode device for stimulation of spinal motoneurons

3rd International School and Conference on Optoelectronics, Photonics, Engineering and Nanostructures (Saint Petersburg OPEN 2016)

Matveev, M.V.^1 ; Erofeev, A.I.^1,2 ; Zakharova, O.A.^1,2 ; Pyatyshev, E.N.^3 ; Kazakin, A.N.^3 ; Vlasova, O.L.^1,2

Department of Medical Physics, Peter the Great St. Petersburg Polytechnic University, Saint-Petersburg

195251, Russia^1

Molecular Neurodegeneration Lab, Peter the Great Polytechnic University, Saint- Petersburg

195251, Russia^2

Nano and Microsystem Technology Lab, Peter the Great Polytechnic University, Saint-Petersburg

195251, Russia^3

关键词: Fiber optic light;    Genetically modified;    Implanted device;    Manufacturing techniques;    Micro-system technologies;    Multi-channel recording;    Neurodegeneration;    Scientific researches;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/741/1/012071/pdf
DOI  :  10.1088/1742-6596/741/1/012071

来源: IOP

【 摘 要 】

Recent years, optogenetic method of scientific research has proved its effectiveness in the nerve cell stimulation tasks. In our article we demonstrate an implanted device for the spinal optogenetic motoneurons activation. This work is carried out in the Laboratory of Molecular Neurodegeneration of the Peter the Great St. Petersburg Polytechnic University, together with Nano and Microsystem Technology Laboratory. The work of the developed device is based on the principle of combining fiber optic light stimulation of genetically modified cells with the microelectrode multichannel recording of neurons biopotentials. The paper presents a part of the electrode implant manufacturing technique, combined with the optical waveguide of ThorLabs (USA).