More QACs, more questions: Recent advances in structure activity relationships and hurdles in understanding resistance mechanisms

TETRAHEDRON LETTERS

卷:60

Article

Morrison, Kelly R.¹  Allen, Ryan A.¹  Minbiole, Kevin P. C.²  Wuest, William M.^1,3 

[1] Emory Univ, Dept Chem, 1515 Dickey Dr, Atlanta, GA 30322 USA

[2] Villanova Univ, Dept Chem, 800 E Lancaster Ave, Villanova, PA 19085 USA

[3] Emory Univ, Antibiot Resistance Ctr, Sch Med, 201 Dowman Dr, Atlanta, GA 30322 USA

关键词: Quaternary ammonium compounds;    Disinfectants;    Antibiotic resistance;    MultiQACs;    Efflux Pumps;   

DOI  :  10.1016/j.tetlet.2019.07.026

来源: Elsevier

【 摘 要 】

Quaternary ammonium compounds (QACs) are a class of antimicrobials that have been around for over a century; nevertheless, they have found continued renewal in the structures to which they can be appended. Ranging from antimicrobial polymers to adding novel modes of action to existing antibiotics, QACs have found ongoing use due to their potent properties. However, resistance against QACs has begun to emerge, and the mechanism of resistance is still only partially understood. In this review, we aim to summarize the current state of the field and what is known about the mechanisms of resistance so that the QACs of the future can be designed to be evermore efficacious and utilized to unearth the remaining mysteries that surround bacteria's resistance to them. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free