Trivalent sulfonium compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:37

Article

Feliciano, Javier A.¹  Leitgeb, Austin J.¹  Schrank, Cassandra L.²  Allen, Ryan A.²  Minbiole, Kevin P. C.¹  Wuest, William M.²  Carden, Robert G.¹ 

[1] Villanova Univ, Dept Chem, Villanova, PA 19085 USA

[2] Emory Univ, Dept Chem, 1515 Pierce Dr, Atlanta, GA 30322 USA

关键词: Antiseptics;    Trivalent sulfonium compounds;    Quaternary ammonium compounds;    Benzalkonium chloride;    Methicillin-resistant Staphylococcus aureus (MRSA);   

DOI  :  10.1016/j.bmcl.2021.127809

来源: Elsevier

【 摘 要 】

Recent advances in the development of quaternary ammonium compounds (QACs) have focused on new structural motifs to increase bioactivity, but significantly less studied has been the change from ammonium-to sulfonium-based disinfectants. Herein, we report the synthesis of structurally analogous series of quaternary ammonium and trivalent sulfonium compounds (TSCs). The bioactivity profiles of these compounds generally mirror each other, and the antibacterial activity of sulfonium-based THT-18 was found to be comparable to the commercial disinfectant, BAC. The development of these compounds presents a new avenue for further study of disinfectants to combat the growing threat of bacterial resistance.

【 授权许可】

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