Loading and release of drugs inside the cavity of halloysite nanotubes

International Fundamentum Science Symposium 2018

自然科学;工业技术

Wahab, I.F.^1 ; Zailani, N.^1 ; Razak, S.I.A.^1,2 ; Nayan, N.H.M.^3

Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Skudai Johor

81310, Malaysia^1

IJN-UTM Cardiovascular Engineering Centre, Universiti Teknologi Malaysia, Skudai, Johor

81310, Malaysia^2

Faculty of Engineering Technology, Universiti Tun Hussein Onn Malaysia, Pagoh Education Hub, KM 1, Jln Panchor, Panchor, Johor

84600, Malaysia^3

关键词: Benzalkonium chloride;    Biodistributions;    Halloysite nanotubes;    Loading efficiency;    Material loaded;    Pharmaceutical science;    Sustained drug release;    Sustained release;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/440/1/012043/pdf
DOI  :  10.1088/1757-899X/440/1/012043

来源: IOP

【 摘 要 】

Recent years have witnessed a huge growth of research in pharmaceutical sciences using nanoparticles as drug transport to reduce toxicity and for more specific drug targeting. Conventional application of drugs has major limitation and drawback since they have limited effectiveness, unsustainable release, and poor biodistribution. Thus this paper aims to produce a suitable material loaded with drugs that can provide an efficient effect of the drug at the site of action and maintain them throughout the treatment. Halloysite nanotubes were used as the material since it fulfills all the criteria needed for sustained drug release. Here, benzalkonium chloride was used as an antiseptic along with methylene blue and methyl orange as the cationic and anionic drug models. All three drugs were loaded into the halloysite lumen by vacuum suction. Result shows the most successful loading efficiency is halloysite loaded with methyl orange where the loading is almost 82% and also shows an excellent sustained release for 19 hours when released in 0.3M hydrochloric acid.