99mTc-ciprofloxacin for diagnosis of bacterial infection

International Nuclear Science and Technology Conference 2014

Aungurarat, A.^1 ; Ngamprayad, T.^1 ; Dangprasert, M.^1 ; Phumkem, S.^1 ; Jowanaridhi, B.^1

Radioisotope Center, Thailand Institute of Nuclear Technology, Bangkok, Thailand^1

关键词: Bacterial infections;    Biodistributions;    Ciprofloxacin;    Non-toxic;    Optimum conditions;    Radiochemical purity;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/611/1/012029/pdf
DOI  :  10.1088/1742-6596/611/1/012029

来源: IOP

【 摘 要 】

Preparation of99mTc-ciprofloxacin for diagnosis of bacterial infection was investigated by varying factors which affected this compound. The optimum conditions for preparation of99mTc-ciprofloxacin and a lyophilized kit for Tc-99m labelling were studied. The results from biodistribution study showed that the percentages of the injected dose per gram tissues of infected area at 1 and 3 hours after injection were around 0.25-0.56.99mTc-ciprofloxacin was found sterile, pyrogen-free and non-toxic. Radiochemical purity was greater than 90% with greater than 6 hours of stability.