The Research Progress of Targeted Drug Delivery Systems

4th International Conference on Advanced Composite Materials and Manufacturing Engineering 2017

材料科学;化学

Zhan, Jiayin^1 ; Ting, Xizi Liang^1 ; Zhu, Junjie^1

School of Chemistry and Chemical Engineering, Nanjing University, Nanjing

210023, China^1

关键词: Biodistributions;    Controlled release drugs;    Conventional drugs;    Dosing systems;    Normal tissue damage;    Targeted drug delivery systems;    Therapeutic properties;    Transdermal drug delivery systems;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/207/1/012017/pdf
DOI  :  10.1088/1757-899X/207/1/012017

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Targeted drug delivery system (DDS) means to selectively transport drugs to targeted tissues, organs, and cells through a variety of drugs carrier. It is usually designed to improve the pharmacological and therapeutic properties of conventional drugs and to overcome problems such as limited solubility, drug aggregation, poor bio distribution and lack of selectivity, controlling drug release carrier and to reduce normal tissue damage. With the characteristics of nontoxic and biodegradable, it can increase the retention of drug in lesion site and the permeability, improve the concentration of the drug in lesion site. at present, there are some kinds of DDS using at test phase, such as slow controlled release drug delivery system, targeted drug delivery systems, transdermal drug delivery system, adhesion dosing system and so on. This paper makes a review for DDS.