Vascular and lung function related to ultrafine and fine particles exposure assessed by personal and indoor monitoring: a cross-sectional study

Environmental Health

Research

Gitte Juel Holst¹  Torben Sigsgaard¹  Aneta Wierzbicka²  Gabriel Bekö³  Birthe Uldahl Kjeldsen³  Geo Clausen³  Allan Linneberg⁴  Dorina Gabriela Karottki⁵  Peter Møller⁵  Ditte Marie Jensen⁵  Yulia Olsen⁵  Lars-Georg Hersoug⁵  Steffen Loft⁵ 

[1] Department of Public Health, Section of Environment, Occupation &, Health, University of Aarhus, Bartholins Allé 2, 8000, Aarhus, Denmark;Division of Ergonomics and Aerosol Technology, Lund University, P.O. Box 118, 221 00, SE, Lund, Sweden;International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark, Nils Koppels Alle 402, 2800, Lyngby, Denmark;Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Nordre Ringvej 57, 2600, Glostrup, Denmark;Department of Clinical Experimental Research, Glostrup University Hospital, Nordre Ringvej 57, 2600, Glostrup, Denmark;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark;Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5A, 1014, Copenhagen, Denmark;

关键词: Indoor air pollution;    Ambient air pollution;    Ultrafine particles;    Personal monitoring;    Microvascular function;    Inflammation;    Lung function;   

DOI  :  10.1186/1476-069X-13-112

 received in 2014-06-30, accepted in 2014-12-08,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundExposure to ambient air particulate matter (PM) has been linked to decline in pulmonary function and cardiovascular events possibly through inflammation. Little is known about individual exposure to ultrafine particles (UFP) inside and outside modern homes and associated health-related effects.MethodsAssociations between vascular and lung function, inflammation markers and exposure in terms of particle number concentration (PNC; d = 10-300 nm) were studied in a cross-sectional design with personal and home indoor monitoring in the Western Copenhagen Area, Denmark. During 48-h, PNC and PM2.5 were monitored in living rooms of 60 homes with 81 non-smoking subjects (30-75 years old), 59 of whom carried personal monitors both when at home and away from home. We measured lung function in terms of the FEV1/FVC ratio, microvascular function (MVF) and pulse amplitude by digital artery tonometry, blood pressure and biomarkers of inflammation including C-reactive protein, and leukocyte counts with subdivision in neutrophils, eosinophils, monocytes, and lymphocytes in blood.ResultsPNC from personal and stationary home monitoring showed weak correlation (r = 0.15, p = 0.24). Personal UFP exposure away from home was significantly inversely associated with MVF (1.3% decline per interquartile range, 95% confidence interval: 0.1-2.5%) and pulse amplitude and positively associated with leukocyte and neutrophil counts. The leukocyte and neutrophil counts were also positively and pulse amplitude negatively associated with total personal PNC. Indoor PNC and PM2.5 showed positive association with blood pressure and inverse association with eosinophil counts.ConclusionsThe inverse association between personal exposure away from home and MVF is consistent with adverse health effects of UFP from sources outside the home and might be related to increased inflammation indicated by leukocyte counts, whereas UFP from sources in the home could have less effect.

【 授权许可】

Unknown   
© Olsen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.