Association between personal exposure to ambient metals and respiratory disease in Italian adolescents: a cross-sectional study

BMC Pulmonary Medicine

Research Article

Alessandro Marcon¹  Chiara Benedetti²  Marco Nazzaro²  Silvia Zoni²  Chiara Fedrighi²  Filippo Donna²  Marco Peli³  Maria José Rosa⁴  Roberto Lucchini⁵  Rosalind Wright⁶  Neil Zimmerman⁷ 

[1] Department of Diagnostics and Public Health, Unit of Epidemiology & Medical Statistics, University of Verona, Verona, Italy;Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Section of Occupational Medicine, University of Brescia, Brescia, Italy;Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Section of Occupational Medicine, University of Brescia, Brescia, Italy;Department of Civil, Environmental, Architectural Engineering and Mathematics of the University of Brescia, Brescia, Italy;Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, Box 1057, One Gustave L. Levy Place, 10029, New York, NY, USA;Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, Box 1057, One Gustave L. Levy Place, 10029, New York, NY, USA;Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Section of Occupational Medicine, University of Brescia, Brescia, Italy;Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, Box 1057, One Gustave L. Levy Place, 10029, New York, NY, USA;Department of Pediatrics, Pulmonary and Critical Care, Icahn School of Medicine at ’Mount Sinai, New York, NY, USA;School of Health Sciences, Purdue University, West Lafayette, IN, USA;

关键词: Metal;    Personal monitoring;    Adolescent health;    Asthma;    Air pollution;   

DOI  :  10.1186/s12890-016-0173-9

 received in 2015-09-10, accepted in 2016-01-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundRelease of ambient metals during ferroalloy production may be an important source of environmental exposure for nearby communities and exposure to these metals has been linked to adverse respiratory outcomes. We sought to characterize the association between personal air levels of metals and respiratory health in Italian adolescents living in communities with historic and current ferroalloy activity.MethodsAs part of a study in the industrial province of Brescia, Italy, 410 adolescents aged 11–14 years were recruited. Participants were enrolled from three different communities with varying manganese (Mn) levels: Bagnolo Mella which has current ferroalloy activity, Valcamonica, which has historic ferroalloy activity and Garda Lake which has no history of ferroalloy activity. Particulate matter <10 μm in diameter (PM10) was collected for 24 h in filters using personal sampling. Mn, nickel (Ni), zinc (Zn), chromium (Cr) and iron (Fe) were measured in filters using x-ray fluorescence. Data on respiratory health was collected through questionnaire. Data for 280 adolescents were analyzed using a modified Poisson regression, and risk ratios were calculated for an interquartile (IQR) range increase in each pollutant.ResultsIn adjusted models including PM10 as a co-pollutant, we found significant associations between concentrations of Mn (RR: 1.09, 95 % CI [1.00, 1.18] per 42 ng/m3 increase), Ni (RR: 1.11, 95 % CI [1.03, 1.21] per 4 ng/m3 increase) and Cr (RR: 1.08, 95 % CI [1.06, 1.11] per 9 ng/m3 increase) and parental report of asthma. We also found significant associations between increased Mn and Ni and increased risk of asthma medication use in the past 12 months (RR: 1.13, 95 % CI [1.04, 1.29] and (RR: 1.13, 95 % CI [1.01, 1.27] respectively).ConclusionsOur findings suggest that exposure to ambient Mn, Ni and Cr may be associated with adverse respiratory outcomes.

【 授权许可】

CC BY   
© Rosa et al. 2016