Association of apolipoprotein E polymorphism with maximal oxygen uptake after exercise training: a study of Chinese young adult

Lipids in Health and Disease

Research

Huiru Wang¹  Qi Qi²  Wenhua Chen²  Kunpeng Li²  Wen Zhang²  Renwei Wang³  Bo Yu⁴ 

[1] Department of Physical Education, Shanghai Jiao Tong University, 200240, Shanghai, China;Department of Rehabilitation Medicine, Shanghai First People’s Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China;School of Kinesiology, Shanghai University of Sport, 200438, Shanghai, China;School of Kinesiology, Shanghai University of Sport, 200438, Shanghai, China;Department of Rehabilitation Medicine, Shanghai First People’s Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China;

关键词: Apolipoprotein E;    Gene polymorphism;    Maximal oxygen uptake;    Exercise training;   

DOI  :  10.1186/1476-511X-13-40

 received in 2014-02-04, accepted in 2014-02-21,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundAlthough a few studies have been conducted, it is still unclear whether the apolipoprotein E (APOE) polymorphism is associated with maximal oxygen uptake (VO2max) after exercise training. The objective of this study was to examine if the APOE gene polymorphisms affect VO2max after exercise training in Chinese young adult.MethodsA total of 360 Chinese young adult (180 male and 180 female) were recruited into this gender-specific cohorts. Anthropometrics, serum lipids, and VO2max were measured pre and post 6 months of supervised exercise training. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the APOE gene polymorphisms.ResultsVO2max after exercise training increased significantly higher in carriers of E2/E3 in male [odds ratio (OR) =0.68, 95% confidence interval (CI) = 0.04, 1.32; P = 0.04] and female (OR =0.62, 95% CI = 0.05, 1.18; P = 0.03). VO2max after exercise training increased significantly higher in carriers of E3/E4 in male (OR =0.60, 95% CI = 0.09, 1.11; P = 0.02) and female (OR =0.62, 95% CI = 0.09, 1.15; P = 0.02). No significant differences were found in carriers of E2/E2, E2/E4, E3/E3, E4/E4 in either male nor female.ConclusionOur study found that APOE gene polymorphism was associated with VO2max levels after exercise training in Chinese young adult. In the future, further experiments will be necessary to confirm this finding and to find the possible mechanism.

【 授权许可】

Unknown   
© Yu et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.