Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies

Lipids in Health and Disease

Research

Wenyin Luo¹  Yijun Wei¹  Jianxin Liu¹  Rongjun Zhang¹  Xiaofeng Wang¹  Zongchun Tang¹  Bobo Chen¹  Jialong Li¹  Jun Wang¹  Shuzhen Yang¹  Youbing Zhang¹  Kunhu Zhang¹ 

[1] Department of Neurosurgery, Third Hospital of Chinese PLA, 45 Dongfeng Road, Jin Tai District, 721004, Baoji, Shanxi Province, China;

关键词: Apolipoprotein E;    Intracerebral hemorrhage;    Gene polymorphism;    Meta-analysis;   

DOI  :  10.1186/1476-511X-13-47

 received in 2013-09-12, accepted in 2013-09-20,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundStudies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship.MethodsPublished literature from the National Library of Medline and Embase databases were retrieved. Odds ratio (OR) and 95% confidence interval (CI) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race.ResultsThis meta-analysis included 11 case–control studies, which included 1,238 ICH cases and 3,575 controls. The combined results based on all studies showed that ICH cases had a significantly higher frequency of APOE ϵ4 allele (OR= 1.42, 95% CI= 1.21,1.67, P<0.001). In the subgroup analysis by race, we also found that ICH cases had a significantly higher frequency of APOE ϵ4 allele in Asians (OR= 1.52, 95% CI= 1.20,1.93, P<0.001) and in Caucasians (OR= 1.34, 95% CI= 1.07,1.66, P=0.009). There was no significant relationship between APOE ϵ2 allele and the risk of ICH.ConclusionOur meta-analysis suggested that APOE ϵ4 allele was associated with a higher risk of ICH.

【 授权许可】

Unknown   
© Zhang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.