Association of apolipoprotein E polymorphism with maximal oxygen uptake after exercise training: a study of Chinese young adult

Lipids in Health and Disease

Huiru Wang³  Wen Zhang¹  Kunpeng Li¹  Qi Qi¹  Renwei Wang²  Wenhua Chen¹  Bo Yu¹ 

[1] Department of Rehabilitation Medicine, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China;School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China;Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China

关键词: Exercise training;    Maximal oxygen uptake;    Gene polymorphism;    Apolipoprotein E;   

Others  :  811199
DOI  :  10.1186/1476-511X-13-40

 received in 2014-02-04, accepted in 2014-02-21,  发布年份 2014

【 摘 要 】

Background

Although a few studies have been conducted, it is still unclear whether the apolipoprotein E (APOE) polymorphism is associated with maximal oxygen uptake (VO_2max) after exercise training. The objective of this study was to examine if the APOE gene polymorphisms affect VO_2max after exercise training in Chinese young adult.

Methods

A total of 360 Chinese young adult (180 male and 180 female) were recruited into this gender-specific cohorts. Anthropometrics, serum lipids, and VO_2max were measured pre and post 6 months of supervised exercise training. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the APOE gene polymorphisms.

Results

VO_2max after exercise training increased significantly higher in carriers of E2/E3 in male [odds ratio (OR) =0.68, 95% confidence interval (CI) = 0.04, 1.32; P = 0.04] and female (OR =0.62, 95% CI = 0.05, 1.18; P = 0.03). VO_2max after exercise training increased significantly higher in carriers of E3/E4 in male (OR =0.60, 95% CI = 0.09, 1.11; P = 0.02) and female (OR =0.62, 95% CI = 0.09, 1.15; P = 0.02). No significant differences were found in carriers of E2/E2, E2/E4, E3/E3, E4/E4 in either male nor female.

Conclusion

Our study found that APOE gene polymorphism was associated with VO_2max levels after exercise training in Chinese young adult. In the future, further experiments will be necessary to confirm this finding and to find the possible mechanism.

【 授权许可】

   
2014 Yu et al.; licensee BioMed Central Ltd.

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