Pathological impairments induced by interstitial implantation of 125I Seeds in spinal canal of banna mini-pigs

World Journal of Surgical Oncology

Research

Yongqing Xu¹  Zuozhang Yang²  Jinlei Zhang³  Hongpu Sun³  Hua Jiang³  Lie Xu³  Ruilian Zhao³  Jin Zhang³  Xiaoxue Wang³  Dakuan Yang⁴ 

[1] Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, 650118, Kunming, Yunnan, P. R. China;Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, 650118, Kunming, Yunnan, P. R. China;Department of Orthopedics, Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, 650118, Kunming, Yunnan, P. R. China;Department of Orthopedics, Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, 650118, Kunming, Yunnan, P. R. China;The Second Affiliated Hospital of Kunming Medical University, 650118, Kunming, Yunnan, P. R. China;

关键词: Brachytherapy;    I seed;    Radiation myelopathy;    banna mini-pig;   

DOI  :  10.1186/1477-7819-10-48

 received in 2011-08-23, accepted in 2012-03-05,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundUse a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.MethodsIn present study, 125I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.ResultsIn this study, a 125I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.ConclusionsWithout any protection and operation improvement, 125I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.

【 授权许可】

CC BY   
© Yang et al; licensee BioMed Central Ltd. 2012