Percutaneous vertebroplasty combined with interstitial implantation of 125I seeds in banna mini-pigs

World Journal of Surgical Oncology

Xuefeng Liu³  Yanjin Chen³  Lei Xu³  Hongpu Sun³  Jiaping Wang¹  Hua Jiang¹  Barbara Rossi⁴  Giulio Maccauro⁴  Da Xu³  Yu Zhang²  Zuozhang Yang³ 

[1] Department of Radiology, The Second Affiliated Hospital of Kunming Medical University, 650118, Kunming, Yunnan, P. R. China;Department of Orthopedics, Peking Union Medical College Hospital, 100730, Beijing, P.R. China;Department of Orthopedics, Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, 650118, Kunming, Yunnan, P. R. China;Department of Orthopaedics and Traumatology, Agostino Gemelli Hospital, Catholic University of Rome, Largo Francesco Vito 1, 00135, Rome, Italy

关键词: Radiation myelopathy;    ¹²⁵I seeds;    Brachytherapy;    Percutaneous vertebroplasty;   

Others  :  826207
DOI  :  10.1186/1477-7819-11-46

 received in 2012-10-11, accepted in 2013-02-06,  发布年份 2013

【 摘 要 】

Background

Although brachytherapy is one of the most effective ways to treat metastatic spinal tumor with little damage to surrounding healthy tissue, it may cause radiation myelopathy if an overdose occurs. Establishing a valuable animal model can help to find a method to overcome its complications. In the current study, we set up a banna mini-pig model to mimic percutaneous vertebroplasty with ¹²⁵I seed implantation.

Methods

Percutaneous vertebroplasty (PVP) combined with interstitial implantation of ¹²⁵I seeds, ¹²⁵I seeds were transplanted into the vertebral body at the T13 level of the spine in banna mini-pigs. After raising them for up to eight months, the spinal cord and vertebral body were collected for pathological analysis.

Results

A potential animal model had been successfully established, no case of radiation myelopathy was found in any of the treated banna pigs, and no significant cellular impairment was noted by pathological analysis.

Conclusions

It proves that PVP with ¹²⁵I brachytherapy is an effective method to treat metastasis spinal tumor, and that the banna mini-pig can be a suitable model to investigate the mechanism of brachytherapy complications.

【 授权许可】

   
2013 Yang et al; licensee BioMed Central Ltd.

【 图 表 】

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