Pathological impairments induced by interstitial implantation of 125I Seeds in spinal canal of banna mini-pigs

World Journal of Surgical Oncology

Jinlei Zhang³  Lie Xu³  Hua Jiang³  Xiaoxue Wang³  Jin Zhang³  Ruilian Zhao³  Hongpu Sun³  Dakuan Yang¹  Yongqing Xu²  Zuozhang Yang³ 

[1] The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650118, P. R. China;Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan 650118, P. R. China;Department of Orthopedics, Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650118, P. R. China

关键词: banna mini-pig;    Radiation myelopathy;    ¹²⁵I seed;    Brachytherapy;   

Others  :  827926
DOI  :  10.1186/1477-7819-10-48

 received in 2011-08-23, accepted in 2012-03-05,  发布年份 2012

【 摘 要 】

Background

Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.

Methods

In present study, ¹²⁵I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.

Results

In this study, a ¹²⁵I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.

Conclusions

Without any protection and operation improvement, ¹²⁵I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.

【 授权许可】

   
2012 Yang et al; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Yang Zuozhang, Yang Dakuan, Xie Lin, Sun Yuqing, Huang Yunchao, Sun Hongpu, Liu Pengjie, Wu Zhongxiong: Treatment of metastatic spinal tumors by percutaneous vertebroplasty versus percutaneous vertebroplasty combined with interstitial implantation of 125I seeds. Acta Radiol 2009, 50:1141-1148.
• [2]Jang JS, Lee SH: Efficacy of percutaneous vertebroplasty combined with radiotherapy in osteolytic metastatic spinal tumors. J Neurosurg Spine 2005, 2:243-248.
• [3]Merrick GS, Wallner KE, Butler WM: Permanent interstitial brachytherapy for the management of carcinoma of the prostate gland. J Urol 2003, 169:1643-1652.
• [4]Roeloffzen EM, Monninkhof EM, Battermann JJ, van Roermund JG, Moerland MA, van Vulpen M: Acute urinary retention after I-125 prostate brachytherapy in relation to dose in different regions of the prostate. Int J Radiat Oncol Biol Phys 2010, 80:76-84.
• [5]Rivard MJ, Coursey BM, Hanson WF, Huq MS, Ibbott GS: Update of AAPM task group No. 43 report: A revised AAPM protocol for brachytherapy dose calculations. Med Phys 2004, 31:633-674.
• [6]Rivard MJ, Davis SD, DeWerd LA, Rusch TW, Axelrod S: Calculated and measured brachytherapy dosimetry parameters in water for the Xoft Axxent X-Ray Source: an electronic brachytherapy source. Med Phys 2006, 33:4020-4032.
• [7]Sun L, Li J, Cheng J: Monte Carlo calculations of the dosimetry parameters for the 125-I brachytherapy source. Journal of Tsinghua University(Science and Technology) 2006, 49:1593-1596.
• [8]Maynard FM Jr, Bracken MB, Creasey G, Ditunno JF Jr, Donovan WH, Ducker TB, Garber SL, Marino RJ, Stover SL, Tator CH, Waters RL, Wilberger JE, Young W: International Standards for Neurological and Functional Classification of Spinal Cord Injury. American Spinal Injury Association. Spinal Cord 1997, 35:266-274.
• [9]Miki K, Kiba T, Sasaki H, Kido M, Aoki M, Takahashi H, Miyakoda K, Dokiya T, Yamanaka H, Fukushima M, Egawa S: Transperineal prostate brachytherapy, using I-125 seed with or without adjuvant androgen deprivation, in patients with intermediate-risk prostate cancer: study protocol for a phase III, multicenter, randomized, controlled trial. BMC Cancer 2010, 10:572.
• [10]Barde YA, Dechant G: The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nature Neuroscience 2002, 5:1131-1136.
• [11]Sabatier F, Darmon P, Hugel B, Combes V, Sanmarco M, Velut JG, Arnoux D, Charpiot P, Freyssinet JM, Oliver C, Sampol J, Dignat-George F: Type 1 and type 2 diabetic patients display different patterns of cellular microparticles. Diabetes 2002, 51:2840-2845.
• [12]Charyulu K, Block N, Sudarsanam A: Preoperative extended field radiation with I-125 seed implant in prostatic cancer: a preliminary report of a randomized study. Int J Radiat Oncol Biol Phys 1979, 5:1957-1961.
• [13]Imamura K, McKinnon M, Middleton R, Black N: Reliability of a comorbidity measure: the Index of Co-Existent Disease(ICED). J Clin Epidemiol 1997, 50:1011-1016.
• [14]Bogart JA, Ungureanu C, Shihadeh E, Chung TC, King GA, Ryu S, Kent C, Winfield JA: Resection and permanent I-125 brachytherapy without whole brain irradiation for solitary brain metastasis from non-small cell lung carcinoma. J Neurooncol 1999, 44:53-57.
• [15]Lee W, Daly BD, DiPetrillo TA, Morelli DM, Neuschatz AC, Morr J, Rivard MJ: Limited resection for non-small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds. Ann Thorac Surg 2003, 75:237-42. discussion 242-243