Palliative treatment of pelvic bone tumors using radioiodine (125I) brachytherapy

World Journal of Surgical Oncology

Research

Chuanyin Zhang¹  Zhengqi Chen²  Chongren Wang²  Yisilamu Yasin³  Jian Chen⁴  Xiaojun Ma⁴  Jiakang Shen⁴  Zhengdong Cai⁵  Yingqi Hua⁵  Wei Sun⁵ 

[1] Department of Orthopedics, Huashan Hospital Baoshan Branch Affiliated to Fudan University, 200431, Shanghai, China;Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 200072, Shanghai, China;Department of Spine Surgery, Xinjiang People’s Hospital, 830001, Urumqi, Xinjiang Autonomous Region, China;Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China;Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China;Shanghai Bone Tumor Institution, 201620, Shanghai, China;

关键词: Pelvic tumor;    I seed;    Brachytherapy;    Efficacy;    Safety;   

DOI  :  10.1186/s12957-016-1050-y

 received in 2016-04-25, accepted in 2016-11-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundComplete resection of pelvic bone tumors, especially recurrent and metastatic ones, is often impossible to achieve using conventional surgery. This study aimed to assess the benefits and adverse effects of computed tomography (CT)-guided radioiodine (125I) brachytherapy for inoperable recurrent and metastatic bone tumors of the pelvis.MethodsThis was a retrospective study of 22 patients with confirmed pelvic bone tumors (10 females and 12 males; 15–84 years; 21 with primary pelvic tumor and one with pelvic metastasis). CT-guided 125I brachytherapy was performed using 9–21 125I seeds (radioactivity of 0.5–0.7 mCi). Seed implantation was validated by postoperative CT scanning. Complications, pain, survival, and CT-estimated tumor size were carried out to evaluate the therapeutic benefits.ResultsPostoperative CT scans revealed satisfactory 125I seed implantation, and the radiation dose delivered to 90% of the target area (D90) was higher than the prescription dose (PD). No obvious complications were observed. Pain was reported by 19 of 22 patients, but 17 reported pain relief after implantation. Follow-up ranged 8–27 (median, 19) months. Tumor size was reduced in 11 patients within 1 month after surgery, nine patients showed no change, and tumor size increased in two patients. Finally, 1- and 2-year survival was 81.8 and 45.5%, respectively; 1- and 2-year local tumor control rates were 59.1 and 36.4%, respectively.Conclusions125I seed implantation significantly reduced bone tumor size and relieved pain, with a low complication rate. These findings suggest that 125I brachytherapy treatment could be a useful palliative approach for pelvic bone tumor treatment.

【 授权许可】

CC BY   
© The Author(s). 2016